amobarbital will reduce the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.iloperidone boosts levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone is actually a time-dependent CYP3A inhibitor and should bring on enhanced plasma